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Biological Pathway
Cite
curcumin
COX-2 enzyme activity inhibited by curcumin direct binding
PGE2 biosynthesis reduced
EP2/EP4 receptor activation reduced
adenylyl cyclase activity reduced
cAMP levels reduced
PKA(RIIα) activity reduced
CREB(Ser133) phosphorylation reduced
pro-survival gene transcription reduced
BAX/BCL-2 ratio elevated
cytochrome c released
colorectal cancer
Score: 0.90
11 hops
Pathway Hops
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
INHIBITS
Confidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers
curcumin → colorectal cancer — Biological Pathway | InTree.AI | InTree