EGFREGFR activated → RAS-GTP elevatedRAS-GTP → RAF/MEK/ERK cascade activatedERK(Thr202/Tyr204) phosphorylated → MYC(Ser62) stabilisedMYC transcriptional activity elevated → PUMA(BBC3) mRNA upregulatedPUMA protein elevated → BCL-XL BH3-binding groove occupiedBCL-XL sequestration of BAX released → BAX(Ser184) dephosphorylatedBAX conformational changeBAX oligomers inserted into outer mitochondrial membranecytochrome c released into cytosolAPAF1 apoptosome (heptamer) assembledcaspase-9(Asp315) cleaved → caspase-3(Asp175) cleavedapoptosis Score: 0.9012 hops
Pathway Hops
PHOSPHORYLATESConfidence: 95%
UPREGULATESConfidence: 95%
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