EGFREGFR signalling inhibited → PI3K(p110α) activity reducedPI3K reduced → PIP3 levels decreasedPTEN phosphatase activity unopposed → PIP2 accumulatesAKT(Thr308/Ser473) phosphorylation lostAKT-mediated BAX(Ser184) phosphorylation abolishedBAX(Ser184) unphosphorylated → BAX mitochondrial translocation elevatedBAX/BAK heterodimers dissociate → BAK(Thr163) dephosphorylatedMOMP triggered → cytochrome c releasedcaspase-9(Asp315) activated → caspase-3(Asp175) cleavedapoptosis Score: 0.9010 hops
Pathway Hops
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
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