MetforminComplex I inhibited at mitochondrial inner membraneAMP:ATP ratio elevatedAMPK(Thr172) phosphorylated by LKB1FOXO3a(Ser413) phosphorylated by AMPKFOXO3a nuclear translocation elevatedBIM (BCL2L11) transcription elevatedBCL-2 sequestered by BIMcytochrome c released from mitochondriacaspase-9(Asp315) cleavedcaspase-3(Asp175) cleavedCancer
Score: 0.9011 hops
Pathway Hops
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
ACTIVATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
INDUCESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
INHIBITSConfidence: 95%
ACTIVATESConfidence: 95%
INDUCESConfidence: 95%
INDUCESConfidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers
Metformin → Cancer — Biological Pathway | InTree.AI | InTree