aspirin → inflammation — Biological Pathway | InTree.AI

Biological Pathway

aspirinaspirin donates acetyl group to IKKβ(Lys147) directlyIKKβ kinase activity allosterically impairedIκBα(Ser32/36) phosphorylation abolishedIκBα proteolytic degradation by 26S proteasome blockedNF-κB(p65) nuclear import via importin-α3 reducedp65(Ser276) phosphorylation by MSK1 attenuatedp300/CBP co-activator recruitment to NF-κB target promoters impairedICAM-1 and VCAM-1 transcription suppressedleukocyte transendothelial migration reducedinflammation

Score: 0.9010 hops

Pathway Hops

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

SUPPRESSESConfidence: 95%

ASSOCIATED WITHConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers