Metformin → Cancer — Biological Pathway | InTree.AI

Biological Pathway

MetforminComplex I inhibited at mitochondrial inner membraneAMP:ATP ratio elevatedAMPK(Thr172) phosphorylated by LKB1HMGCR(Ser872) phosphorylated by AMPKHMGCR catalytic activity inhibitedmevalonate pathway flux reducedcholesterol and isoprenoid synthesis reducedRAS and RHO prenylation reducedoncogenic RAS membrane anchoring impairedproliferative MAPK signaling attenuatedCancer

Score: 0.9011 hops

Pathway Hops

INHIBITSConfidence: 95%

ACTIVATESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

SUPPRESSESConfidence: 95%

INHIBITSConfidence: 95%

SUPPRESSESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers