Metformin → Cancer — Biological Pathway | InTree.AI

Biological Pathway

MetforminComplex I inhibited at mitochondrial inner membranemitochondrial NADH/NAD+ ratio elevatedhepatic gluconeogenesis flux reducedcAMP-response element binding protein (CREB) coactivator CBP displacedCREB(Ser133) phosphorylation-independent target gene repressiongluconeogenic genes (PCK1, G6PC) transcription reducedhepatic glucose output reducedsystemic hyperglycemia reducedinsulin/IGF-1 signaling axis in tumor cells attenuatedCancer

Score: 0.9010 hops

Pathway Hops

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

SUPPRESSESConfidence: 95%

CAUSESConfidence: 95%

INHIBITSConfidence: 95%

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